Overview
The Chapman Lab conducts research at the
intersection of nanotechnology, immunology, and translational medicine. We
focus on the design of targeted vaccines and therapeutics for infectious
diseases and autoimmune disorders, with particular emphasis on modulating B
cell responses and understanding germinal center biology. Our research
integrates bioconjugation chemistry, protein engineering, and drug delivery to
develop next-generation nanomedicines that enable precise control of immune
responses.
Awards
-Leadership & Professional Strategies & Skills Training (LEAPS) Fellow, MIT 2023
-MERIT Emerging Leaders Symposium (Invited Talk), 2023, Memorial Sloan Kettering Cancer Center, New York, New York
-NIH NRSA Fellow, Training Grant in AIDS-Related Research, MIT 2023-2025 (DFCI/NIAID T32 AI 007386)
-Convergence Scholar, Koch Institute, MIT 2023-2024
-Hertz Global Impact Award, ARCS Scholar Fellowship, Georgia Tech 2018-2021
Selected Publications
DNA origami vaccines program antigen-focused germinal centers. Romanov, A., Knappe, G.A., Ronsard, L., Suh, H., Omer, M., Chapman, A.P., Lewis, V.R., Spivakovsky, K., Canales, J., Reizis, B., Tingle, R.D., Cottrell, C.A., Schiffner, T., Lingwood, D., Bathe, M., Irvine, D.J. , Science, 391, eadx6291, (2026) View Abstract
Linking vaccine adjuvant mechanisms of action to function. Ben-Akiva, E.*, Chapman, A.P.*, Mao, T.*, Irvine, D.J. , Science Immunology, 10, eado5937, (2025) View Abstract
Substructure-specific antibodies against fentanyl derivatives. Chapman, A.P., Xu, M., Schroeder, M., Goldstein, J.M., Chida, A., Lee, J.R., Tang, X., Goldstein, J.M., Wharton, R., Finn, M.G. , ACS Nano, 19, 3714-3725, (2025) View Abstract
Rapid Development of Neutralizing and Diagnostic SARS-CoV-2 Mouse Monoclonal Antibodies. Chapman, A.P., Tang, X., Lee, J.R., Chida, A., Mercer, K., Wharton, R.K., Kainulainen, M., Harcourt, J.L., Martines, R.B., Schroeder, M., Zhao, L., Bryskin, A., Zhou, B., Bergeron, E. Bollweg, B., Tamin, A., Thornburg, N., Wentworth, D.E., Petway, D., Bagarozzi, Jr., D., Finn, M.G., Goldstein, J.M. , Scientific Reports, 11, 9682, (2021) View Abstract
Programmable Multi-stage Drug Delivery to Lymph Nodes. Schudel, A., Chapman, A.P., Yau, M., Higginson, C., Rohner, J., Finn, M.G., Thomas, S.N., Nature Nanotechnology, 15, 491-499, (2020) View Abstract
Education
Ph.D., Biochemistry, Georgia Institute of Technology, 2021B.A., Religious Studies, Agnes Scott College, 2006